Ever since the roundup of 21+ essential iPhone apps with sexy interfaces crashed my hosting server (!), I understand how much people love roundups of well designed apps.

This post is a round up of 50 handpicked Mac apps that have either well designed or have really sexy interfaces or both! They’re not arranged in any order, just random.

I know it’s a giant list to digest, so bookmark this for future reference! Also, leave a comment if you think I have missed out a Mac app of this category.

Pixelmator

[$59 | Website]

Pixelmator is a great alternative to Photoshop, low memory footprint and extremely beautiful.

Tapedeck

[$25 | Website]

TapeDeck is a powerful and fun new audio recorder for Mac OS X Leopard. It’s just like your old analog tape recorder, only better. A lot better.

Snowtape

[$29 | Website]

Snowtape lets you listen to radio stations and record them live. And more! Read my review.

Delibar

[$18 | Website]

I have a review for Delibar coming up next week, so stay tuned! Delibar is a full featured Delicious.com Mac client. Delibar focuses on giving Mac OS X users an easy and quick tool for searching, managing and sharing their Delicious bookmarks.

CleanMyMac

[$29.95 lifetime or $14.95 6 month license | Website]

CleanMyMac represents sophisticated all-in-one-suite utility that helps keep your Mac clean and healthy. With just two simple clicks you can delete useless files that basically pile up and waste your valuable disk space.

Swatch

[$4.95 | Website]

Swatch lets you group your colors together in ‘Swatches’ to later be used throughout your project. Working in CSS? Easily copy the hex value to paste right into your stylesheet.

Snippet

[$12.95 | Website]

An unobstrusive snippets management tool for your Mac.

Anxiety

[Donationware | Website]

Anxiety is a super-lightweight To-do list application for Mac OS X Leopard that synchronizes with iCal and Mail. Its aim is to provide a streamlined, easily accessible interface to add and check off your tasks, while remaining poised to melt into the background at a moments notice.

Capo

[$49 | Website]

Capo is a musician’s best friend. It lets you slow down your favorite songs, so you can hear the notes and learn how they are played.

Bodega

[Free | Website]

Bodega is like Apple’s App Store, but for Mac! Extremely well designed to say the least.

Blogo

[$25 | Website]

Blogo is a blogging app for Mac that supports Wordpress, Blogger, Typepad, Typo, Drupal, Joomla, and Expression Engine. This post is composed speedily with Blogo!

LittleSnapper

[$39 | Website]

LittleSnapper is a screenshot snapping and management app.

Things

[$49.95 | Website]

If you only have budget for only one Mac OS X to-do list tool, look no further than Things. There is also an iPhone app that can sync with Things for Mac

The Hit List

[$49.95 | Website]

Another to-do list tool for Mac, more fancy design, no iPhone app yet.

Notebook

[$49.95 | Website]

More than just an outliner or text processor, NoteBook is idea management software that supports Mac users at every stage of a project, no matter how large or small.

Coverstream

[€14.95| Website]

Control, search and browse music unobstrusive with a coverflow like interface. Gorgeous!

Tangerine

[$24.95 | Website]

Tangerine! lets you easily create playlists of upbeat music, or playlists for relaxing. It works by analyzing the BPM and the beat intensity of your music. Spend your time listening to music, not making playlists.

TuneUp

[$29.95 lifetime or $19.95 annual license | Website]

Your music collection is a mess. TuneUp fixes it. Automagically.

Coversutra

[$19.95 | Website]

CoverSutra gives you a handy and attractive way to control iTunes without having to leave your current application.

Notify

[Free | Website]

Notify provides a simple and elegant way of keeping track of what’s in your Gmail inbox. With support for multiple accounts, and a beautiful tabbed user interface, you can’t go wrong with Notify.

Just Notes

[Donationware | Website]

A simple, beautiful and powerful notes app. The nice user interface lets you focus on the important things – taking notes

Postbox

[$39.95 | Website]

Postbox lets you work with email the way you’ve always wanted. Powered by an ultra-fast email engine and a sharp-looking, intuitive interface, Postbox will help you focus, save time, and get more done.

NewsLife

[$14.88 | Website]

NewsLife is the simplest way to stay up-to-date with tons of websites without even having to touch your web browser until you see something you want to read.

Stuf

[£12.99 | Website]

Stuf is a clipboard manager with a beautiful HUD like interface.

Cha-Ching

[Free during beta | Website]

My personal favorite finance management app. Manage your finances quickly and easily with Cha-Ching 2 for the Mac. Quickly create a budget, enter transactions and track spending, all within a beautiful user interface that will make managing your finances a true pleasure.

Awaken

[CAD$15 | Website]

Gently fall asleep with the sleep timer and wake up on time with Awaken.

Fontcase

[$56 | Website]

A beautiful font management app!

DaisyDisk

[$19.95 | Website]

With DaisyDisk you can free up disk space by quickly finding and deleting big, useless files. The program scans any mounted disk and displays it on the sunburst map, where segments mean files and folders, proportionally to their sizes. The map is easy to read and navigate. You can also quickly preview any file and reveal it in Finder to delete.

iStat Menu

[Free | Website]

The most advanced system monitor for Mac, and dare I say the most beautiful.

Dropzone

[$10 | Website]

Dropzone is a Mac application that makes it faster, easier and more fun to get things done on your Mac. Share files and text, launch applications and extend via a powerful ruby based API.

Midnight Inbox

[$35 | Website]

Midnight Inbox helps you work smarter and with less stress, automating your inputs and organizing your tasks, files, and information so that you can always be in control. Collect emails, files, calendar and to-do items and notes automatically. Process all of your collected items into to-do items you can actually do when and where you are able. Organize those to-do items into projects you can track easily. Review your lists, projects, and collections to make sure nothing slips through the cracks. Do everything on your lists with a Zen-like focus.

Picturesque

[$29.95 | Website]

Picturesque is a simple app with a simple goal: to make images more beautiful. Whether you are in web or print, your images can benefit from a touch of Picturesque magic.

Aperture

[$199 | Website]

Aperture 2 delivers streamlined tools for moving photos from capture to output with uncompromising quality.

Lightroom

[$299 | Website]

Adobe Photoshop Lightroom 2 software is essential for today’s digital photography workflow. Now you can quickly import, process, manage, and showcase your images — from one shot to an entire shoot. With Lightroom 2, you spend less time in front of the computer and more time behind the lens.

ScreenFlow

[$99 | Website]

Capture the contents of your entire desktop at the same time as your video camera, microphone and computer’s audio. Sophisticated editing tools allow you to create incredible screencasts in no time.The finished result is a QuickTime or Windows Media movie, ready for publishing to your website or blog.

Tweetie

[Free (w/ads) $19.95 (no ads) | Website]

Very low memory footprint and pretty Twitter client for Mac! A standalone iPhone app is also available.

Socialite (previously known as Eventbox)

[Not Available Yet | Download Socialite beta 2 from here | Website]

You can manage your social life on Socialite, an all in one social media client where you can tweet, digg, Facebook, Flickr, read RSS feeds, Google Reader, Reddit and more.

Eventbox has been bought over by RealMacSoftware who subsequently renamed the app as Socialite.

Twistori

[$12 | Website]

Twitter visualization app for Mac.

Canary

[Free | Website]

Canary is a Twitter client that is beautifully designed, fun to use and has everything you’ll ever need. Canary’s user interface is slick and straightforward and helps you do what matters most fast and easily. It does more than you would expect it to and the best part: it’s free with no ads.

Delicious Library

[$40 | Website]

Catalog your books, movies, music, software, toys, tools, electronics, & video games

Tags

[$29 | Website]

File tagging app for Mac.

1Password

[$39.95 | Website]

I wonder what I’ll do without 1Password! 1Password can create strong, unique passwords for you, remember them, and restore them, all directly in your web browser.

Propane

[$20 during beta | Website]

A Mac client for users of Campfire. Campfire^™ is a web-based group chat tool from 37signals^®. It’s like Instant Messaging, only better because it’s designed for groups and runs in your web browser.

Espresso

[€59.95 | Website]

Espresso is a web development app by MacRabbit.

CSSEdit

[€29.95 | Website]

Also created by MacRabbit, CSSEdit lets you, as the name suggest, edit CSS!

Coda

[$99 | Website]

My personal favorite for web development! Text editor + file transfer + svn + css + terminal + books + more = whoah.

Billings

[$39.99 | Website]

Billings is an invoicing and time tracking app.

On The Job

[$39.95 | Website]

Similar to Billings, On The Job gets your invoicing job done.

Rapidweaver

[$79 | Website]

Rapidweaver lets you create beautiful websites quickly and easily!

xScope

[$26.95 | Website]

Want to measure stuff on your screen? xScope can help you get the job done.

Flux 2

[£40 | Website] Suggested by Irfan Q

Flux 2 is an extensible web development tool that enables developers to write HTML, CSS, PHP etc. FTP (including SFTP), Local Disk, and MobileMe are all supported in a completely rewritten publishing system.

Textmate

[£40 | Website] Suggested by svenlito

Peeps who uses Textmate stands by Textmate, they must have done something right as one of the most popular tools for developers.

Writeroom

[$24.95 | Website] Suggested by Powitsjj

For people who enjoy the simplicity of a typewriter, but live in the digital world. WriteRoom is a distraction free writing environment. Unlike the cluttered word processors you’re used to, WriteRoom lets you focus on writing. Also comes with an accompanying iPhone app ($4.99)!

Scrivener

[$39.95 | Website] Suggested by twiedi

Scrivener is a word processor and project management tool created specifically for writers of long texts such as novels and research papers. It won’t try to tell you how to write – it just makes all the tools you have scattered around your desk available in one application.

Vinoteka

[€29.90 | Website] Suggested by William

Vinoteka is a brand new wine cellar management software for Mac. Extremely easy and fun to use, Vinoteka offers a realistic interface to manage your bottles (wine, liquors or spirits) recreate your cellar and organize wine tasting sessions. No matter if wine is new for you or if you already are an expert, Vinoteka is here to make your wine experience the best.

Contactizer

[$119 | Website]

Contactizer Pro is an amazing all-in-one solution for managing, sharing and organizing your personal and business information. Contactizer Pro 3.8 makes your business management experience more efficient, productive and inventive. Following the prodigious success of its predecessor, OD4Contact, many users worldwide continue to choose Contactizer Pro for their calendar, organizational and management needs. Contactizer Pro, specifically built for Mac OS X, provides a wealth of powerful PIM features, all through an innovative, elegant and intuitive interface.

Check out SUBERNOVA online project management tool: